Preclinical

How dietary restrictions, including intermittent fasting, impact gut microbiota and overall human health

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How dietary restrictions, including intermittent fasting, impact gut microbiota and overall human health

In a recent review published in Nutrients, researchers reviewed preclinical and clinical data to analyze gut microbial alterations in various dietary conditions. Study: The Beneficial Effects of Dietary Interventions on Gut Microbiota—An Up-to-Date Critical Review and Future Perspectives. Image Credit: LightField Studios/Shutterstock.com Background Intermittent fasting (IF), a popular dietary intervention, has been studied for its impact on … Read more

Next-generation vaccine candidates protect against multiple strains of influenza and last longer

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Next-generation vaccine candidates protect against multiple strains of influenza and last longer

Recent preclinical results indicate novel next-generation vaccine candidates developed at Cleveland Clinic protect against multiple strains of influenza and last longer than vaccines currently in use. The vaccines are part of Cleveland Clinic’s global vaccine research program, led by Ted Ross, PhD, Global Director of Vaccine Development at Cleveland Clinic. Published in Scientific Reports, the … Read more

Redefining the battle against Alzheimer’s with tau-focused treatments

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Redefining the battle against Alzheimer’s with tau-focused treatments

In a recent article published in the journal Nature Reviews Neurology, researchers discuss the efficacy of tau-targeting Alzheimer’s disease (AD) therapies and strategies that can be implemented to improve these treatments, especially immunotherapies. Study: Tau-targeting therapies for Alzheimer disease: Current status and future directions. Image Credit: Gorodenkoff / Shutterstock.com Background Since 2018, the prevalence of AD has increased … Read more

Impact of ketogenic diets on breast cancer

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Impact of ketogenic diets on breast cancer

In a recent review published in Nutrients, researchers explored the therapeutic potential of the ketogenic diet (KD) for breast cancer (BC). Study: Ketogenic Diet and Breast Cancer: Recent Findings and Therapeutic Approaches. Image Credit: Boontoom Sae-Kor/Shutterstock.com Background BC, the most common cancer in women, is greatly influenced by dietary patterns. The ketogenic diet (KD), characterized by a … Read more

New blood test could detect ovarian cancer early, improve treatment

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New blood test could detect ovarian cancer early, improve treatment

High-grade serous ovarian carcinoma (HGSOC) is the most common type of ovarian cancer. It is also the most lethal form, in part because clinicians do not have effective ways to screen women for it during the cancer’s early stages, when it’s easiest to treat. For patients with a pelvic mass (an abnormal lump or growth … Read more

Breast milk proteins linked to abundance of beneficial bacteria in infants

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Breast milk proteins linked to abundance of beneficial bacteria in infants

More than 320 million years of mammalian evolution has adapted breast milk to meet all the physiological needs of babies: it contains not only nutrients, but also hormones, antimicrobials, digestive enzymes, and growth factors. Furthermore, many of the proteins in breast milk, for example casein and milk fat globule membrane proteins, aren’t just sources of … Read more

Ovarian cancer patients enrolled in first-in-human trial of CAR T cell therapy

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Ovarian cancer patients enrolled in first-in-human trial of CAR T cell therapy

Recently published preclinical data by City of Hope scientists shows the immunotherapy is effective. Advanced ovarian cancer patients are now being enrolled in a Phase 1 first-in-human trial. There are currently few effective treatment options for patients with recurrent ovarian cancer and other solid tumors, but City of Hope researchers are trying to change that. … Read more

New gene-editing tool helps to study single-base mutations in cancer

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New gene-editing tool helps to study single-base mutations in cancer

A change in just one letter in the code that makes up a cancer-causing gene can significantly affect how aggressive a tumor is or how well a patient with cancer responds to a particular therapy. A new, very precise gene-editing tool created by Weill Cornell Medicine investigators will enable scientists to study the impact of … Read more