Breakthrough treatments face manufacturing and efficacy

Breakthrough treatments face manufacturing and efficacy

In a recent review published in Gene Therapy, a group of authors explored the progress and persistent hurdles in gene therapy for inherited blood disorders, malignancies via chimeric antigen receptors (CAR)-T cells, and varied diseases treated with in vivo adeno-associated virus (AAV) vectors, addressing the transformative cures and the economic and manufacturing complexities involved. Study: … Read more

Next-generation vaccine candidates protect against multiple strains of influenza and last longer

Next-generation vaccine candidates protect against multiple strains of influenza and last longer

Recent preclinical results indicate novel next-generation vaccine candidates developed at Cleveland Clinic protect against multiple strains of influenza and last longer than vaccines currently in use. The vaccines are part of Cleveland Clinic’s global vaccine research program, led by Ted Ross, PhD, Global Director of Vaccine Development at Cleveland Clinic. Published in Scientific Reports, the … Read more

Ovarian cancer patients enrolled in first-in-human trial of CAR T cell therapy

Ovarian cancer patients enrolled in first-in-human trial of CAR T cell therapy

Recently published preclinical data by City of Hope scientists shows the immunotherapy is effective. Advanced ovarian cancer patients are now being enrolled in a Phase 1 first-in-human trial. There are currently few effective treatment options for patients with recurrent ovarian cancer and other solid tumors, but City of Hope researchers are trying to change that. … Read more